Hansen-Leth C, Karle A
Acta Orthop Scand. 1978 Dec;49(6):557-64. doi: 10.3109/17453677808993238.
The vascular changes in the amputation stump after amputation on an extremity which is vascularized by collaterals were studied by arteriography in adult rabbits. Amputation on the crus immediately after ligature of the femoral artery caused a retardation in the development of collaterals and a protracted vasoconstriction in the amputation stump. Osseous plugging of the medullary cavity in the amputation stump counteracted the vasoconstriction, and the development of collaterals was improved. When amputation on the crus was performed 3-6 days after ligature of the femoral artery, immediate function of the collaterals and a rapid dilatation of the arteries in the below knee amputation stump were seen, and 3--4 weeks postoperatively arteriovenous shunts developed in the stump. Amputation 7--10 weeks after ligature of the artery involved a more pronounced shunt development in the amputation stump. After amputation on the femur only slight differences were observed in the development of collaterals and the vascularization in the amputation stump compared with findings after amputation on the crus.
通过对成年兔进行动脉造影，研究了由侧支血管供血的肢体截肢后残端的血管变化。在股动脉结扎后立即对小腿进行截肢，会导致侧支血管发育迟缓以及截肢残端长期血管收缩。截肢残端髓腔的骨填塞可抵消血管收缩，并改善侧支血管的发育。当在股动脉结扎后3 - 6天对小腿进行截肢时，可见侧支血管立即发挥作用，并且膝下截肢残端的动脉迅速扩张，术后3 - 4周残端出现动静脉分流。动脉结扎后7 - 10周进行截肢，截肢残端的分流发育更为明显。与小腿截肢后的结果相比，仅在股骨截肢后，侧支血管发育和截肢残端的血管化方面观察到轻微差异。
