Roethe R A, Fuller P B, Byrd R B, Hafermann D R
Chest. 1980 Mar;77(3):400-2. doi: 10.1378/chest.77.3.400.
By obtaining five transbronchoscopic biopsies of the lung from each of the right upper and lower lobes, the diagnosis of sarcoidosis was made in 36 of 37 prospectively studied patients. The diagnosis was made in all ten patients with stage-1 disease, but seven of the ten showed diagnostic tissue from only one lobe. Only one of the ten biopsies was diagnostic in four of those patients with a stage-1 disease. In disease of stage 2 and 3, there was good correlation between diagnostic biopsies and the radiographic distribution of infiltrates. Biopsies from the predominantly rather than the lesser involved lobe proved the diagnosis in all of these patients, except for the two patients with nodular sarcoid. We conclude that ten biopsies are optimal for obtaining the diagnosis in stage-1 disease; however, five biopsies may be adequate in non-nodular disease of stage 2 and 3 if the biopsies are of the lobe predominantly involved on the roentgenogram of the chest.
通过从右上叶和右下叶各获取五份经支气管肺活检样本，在37例前瞻性研究的患者中，有36例确诊为结节病。所有10例1期疾病患者均得以确诊，但其中10例中有7例仅在一个肺叶发现诊断性组织。在这10例1期疾病患者中，有4例仅1份活检样本具有诊断意义。在2期和3期疾病中，诊断性活检与浸润影的影像学分布之间存在良好的相关性。除2例结节性结节病患者外，从主要受累而非较少受累的肺叶获取的活检样本证实了所有这些患者的诊断。我们得出结论，对于1期疾病，10份活检样本最有利于确诊；然而，对于2期和3期非结节性疾病，如果活检样本取自胸部X线片上主要受累的肺叶，5份活检样本可能就足够了。
