Human neuropharmacological findings with oxapadol (MD 720111), a new non-narcotic analgesic.

The effects of oxapadol, a new non-narcotic analgesic, were tested in man using the electrically-induced nociceptive flexion reflex in the flexor muscles of the lower limb as an index of pain. The drug caused a significant increase in the threshold of the reflex whereas no change was noted with placebo.