新型非麻醉性镇痛药奥沙帕朵（MD 720111）的人体神经药理学研究结果
Human neuropharmacological findings with oxapadol (MD 720111), a new non-narcotic analgesic.
作者信息
Boureau F, Laquais B, Vadrot M, Willer J C
出版信息
Experientia. 1980 Jan 15;36(1):97-8. doi: 10.1007/BF02003997.
PMID:7358147
Abstract
The effects of oxapadol, a new non-narcotic analgesic, were tested in man using the electrically-induced nociceptive flexion reflex in the flexor muscles of the lower limb as an index of pain. The drug caused a significant increase in the threshold of the reflex whereas no change was noted with placebo.
摘要
一种新型非麻醉性镇痛药奥沙帕朵的效果在人体中进行了测试，采用下肢屈肌的电诱发伤害性屈曲反射作为疼痛指标。该药物使反射阈值显著提高，而安慰剂则无此变化。
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