Yoshida A, Yokono O, Oda T
Gastroenterol Jpn. 1980;15(1):41-8. doi: 10.1007/BF02773703.
Effects of intravenously administered protease inhibitors on naturally occurring serum inhibitors were investigated in rabbits. Water-dispersed chlorophyll-a, trasylol and leupeptin were tested as exogenous protease inhibitors in the experiments. From the results of experiments, it was concluded that: 1) Pretreatment with chlorophyll-a infusion into rabbits, most effectively prevented the rapid consumption of naturally occurring serum protease inhibitors after successive trypsin infusion, and the duration of its action was observed longest when compared with other exogenous inhibitors, such as trasylol or leupeptin. 2) Final therapeutic effects of these exogenous protease inhibitors seem to have depended upon the disappearing way of the administered inhibitors from the blood in certain period of time, as well as upon biochemical potency of their inhibiting activity.
在兔子身上研究了静脉注射蛋白酶抑制剂对天然存在的血清抑制剂的影响。在实验中测试了水分散性叶绿素a、抑肽酶和亮抑酶肽作为外源性蛋白酶抑制剂。从实验结果得出以下结论：1）给兔子输注叶绿素a进行预处理，能最有效地防止连续输注胰蛋白酶后天然存在的血清蛋白酶抑制剂的快速消耗，并且与其他外源性抑制剂如抑肽酶或亮抑酶肽相比，其作用持续时间观察到最长。2）这些外源性蛋白酶抑制剂的最终治疗效果似乎取决于在一定时间段内给药抑制剂从血液中的消失方式，以及它们抑制活性的生化效力。
