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依次给予肌肉注射接种肉瘤180的小鼠时，丙帕锗与肌苷的化疗增效作用超相加。

Overadditive chemotherapeutic synergism of prospidine and inosine when given sequentially to the Sarcoma 180 implanted intramuscularly.

作者信息

Osswald H, Youssef M

出版信息

J Cancer Res Clin Oncol. 1980 Jan;96(1):115-9. doi: 10.1007/BF00412902.

DOI:10.1007/BF00412902
PMID:7358769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12253889/
Abstract

The chemotherapeutic effectiveness of prospidine monotherapy on the Sarcoma 180 implanted i.m. was compared with several prospidine/inosine combinations. The chemotherapeutic action of the combination was enhanced overadditively when inosine was given 6 h after prospidine. This particular combination caused not only a significant curative action and tumor inhibition as compared with prospidine monotherapy, but also decreased the toxic effects.

摘要

将丙脒腙单一疗法对肌肉注射接种的肉瘤180的化疗效果与几种丙脒腙/肌苷组合进行了比较。当在丙脒腙给药6小时后给予肌苷时，该组合的化疗作用增强且超过相加作用。与丙脒腙单一疗法相比，这种特定组合不仅具有显著的治愈作用和肿瘤抑制作用，而且还降低了毒性作用。

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本文引用的文献

1
[Clinical use of prospidine].[丙帕他莫的临床应用]
Vopr Onkol. 1970;16(8):36-41.
2
[Antitumor activity of prospidin].[普罗司啶的抗肿瘤活性]
Vopr Onkol. 1970;16(7):83-6.
3
[Clinical evaluation of different methods of treating Kaposi's angioreticulosis (Kaposi's sarcoma)].[不同治疗卡波西血管内皮瘤（卡波西肉瘤）方法的临床评估]
Vestn Dermatol Venerol. 1971;45(3):8-15.
4
Metabolic conditioning and metabolic actuation: experimental approaches to cancer chemotherapy involving combinations of metabolites and antimetabolites.代谢调节与代谢激活：涉及代谢物与抗代谢物组合的癌症化疗实验方法
Cancer Chemother Rep. 1974 Jul-Aug;58(4):471-7.
5
[Potentiation of the chemotherapeutic effect of vinblastine by thymidine].[胸苷对长春碱化疗效果的增强作用]
Arzneimittelforschung. 1972 Aug;22(8):1421.
6
[Overadditive synergism of combinations of cyclophosphamide with thymidine, adenosine or uridine in transplantation tumors].
Arzneimittelforschung. 1972 Jul;22(7):1184-8.
7
[Antineoplastic and antimitotic effect of prospidin in hypophysectomized and thyroidectomized rats with sarcoma 45].
Farmakol Toksikol. 1974 Nov-Dec;37(6):715-7.
8
[Antineoplastic drugs developed in the USSR].[苏联研发的抗肿瘤药物]
Cesk Farm. 1974 Dec;23(10):416-20.
9
[Synergistic effect of the combination of thymidine and cyclophosphamide on Ehrlich ascites tumor].胸苷与环磷酰胺联合应用对艾氏腹水瘤的协同作用
Z Krebsforsch. 1970;74(4):376-82.
10
Drugs that make cancer retreat.能使癌症消退的药物。
Indian J Cancer. 1976 Sep;13(3):296-8.