依次给予肌肉注射接种肉瘤180的小鼠时，丙帕锗与肌苷的化疗增效作用超相加。
Overadditive chemotherapeutic synergism of prospidine and inosine when given sequentially to the Sarcoma 180 implanted intramuscularly.
作者信息
Osswald H, Youssef M
出版信息
J Cancer Res Clin Oncol. 1980 Jan;96(1):115-9. doi: 10.1007/BF00412902.
Abstract
The chemotherapeutic effectiveness of prospidine monotherapy on the Sarcoma 180 implanted i.m. was compared with several prospidine/inosine combinations. The chemotherapeutic action of the combination was enhanced overadditively when inosine was given 6 h after prospidine. This particular combination caused not only a significant curative action and tumor inhibition as compared with prospidine monotherapy, but also decreased the toxic effects.
摘要
将丙脒腙单一疗法对肌肉注射接种的肉瘤180的化疗效果与几种丙脒腙/肌苷组合进行了比较。当在丙脒腙给药6小时后给予肌苷时，该组合的化疗作用增强且超过相加作用。与丙脒腙单一疗法相比，这种特定组合不仅具有显著的治愈作用和肿瘤抑制作用，而且还降低了毒性作用。
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