Shamonki I M, Frumar A M, Tataryn I V, Meldrum D R, Davidson B H, Parthemore J G, Judd H L, Deftos L J
J Clin Endocrinol Metab. 1980 Mar;50(3):437-9. doi: 10.1210/jcem-50-3-437.
Calcitonin secretion was studied in 50 normal females from 20--69 yr of age, with 10 subjects in each decade. Hormone measurements were made by RIA during response to a 10-min infusion of calcium (as the chloride salt) at 3 mg/kg BW. There was a progressive decrease of the calcium-stimulated plasma calcitonin with age. Linear regression analysis demonstrated a significant (P less than 0.05) negative correlation (r = 0.29) between calcitonin response and age. Postmenopausal females had a significantly (P less than 0.01) smaller calcitonin response than premenopausal females. The time of maximum calcitonin response progressively shifted from 10 min in the younger subjects to 20 min in the older subjects. These studies demonstrated that calcitonin secretion decreases with age in females. This decrease may play some role in the pathogenesis of the progressive loss of bone mass which occurs with aging in females.
对50名年龄在20至69岁的正常女性进行了降钙素分泌研究，每十年选取10名受试者。通过放射免疫分析法（RIA）在以3mg/kg体重静脉输注钙（氯化钙盐）10分钟的过程中进行激素测量。随着年龄增长，钙刺激后的血浆降钙素水平逐渐下降。线性回归分析显示，降钙素反应与年龄之间存在显著（P<0.05）负相关（r = 0.29）。绝经后女性的降钙素反应明显（P<0.01）小于绝经前女性。降钙素反应的峰值时间逐渐从年轻受试者的10分钟推迟到老年受试者的20分钟。这些研究表明，女性的降钙素分泌随年龄增长而减少。这种减少可能在女性衰老过程中发生的骨质渐进性丢失的发病机制中起一定作用。
