健康个体和多发性硬化症患者红细胞中亚油酸和花生四烯酸的水平。
Levels of linoleate and arachidonate in red blood cells of healthy individuals and patients with multiple sclerosis.
作者信息
Homa S T, Belin J, Smith A D, Monro J A, Zilkha K J
出版信息
J Neurol Neurosurg Psychiatry. 1980 Feb;43(2):106-10. doi: 10.1136/jnnp.43.2.106.
Abstract
The major fatty acids were measured in total lipid extracts of red blood cells from 23 control subjects and 31 patients with multiple sclerosis. In the healthy control subjects an inverse correlation (r = -0.83) was found between the percentages of linoleate and arachidonate. In the patients such an inverse correlation was not found. The results suggest an abnormality in the red blood cells of patients with multiple sclerosis specifically with regard to the regulation of the relative amounts of unsaturated fatty acids, and this has implications for the possible treatment of multiple sclerosis with dietary supplements.
摘要
对23名对照受试者和31名多发性硬化症患者红细胞的总脂质提取物中的主要脂肪酸进行了测量。在健康对照受试者中，亚油酸和花生四烯酸的百分比之间存在负相关（r = -0.83）。在患者中未发现这种负相关。结果表明，多发性硬化症患者的红细胞存在异常，特别是在不饱和脂肪酸相对含量的调节方面，这对用膳食补充剂治疗多发性硬化症可能具有启示意义。
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