Belin J, Pettet N, Smith A D, Thompson R H, Zilkha K J
J Neurol Neurosurg Psychiatry. 1971 Feb;34(1):25-9. doi: 10.1136/jnnp.34.1.25.
(1) The levels of oleate and linoleate in the serum have been measured in 14 patients with multiple sclerosis (MS) and in 14 healthy subjects before, during and after a five day period when the normal diet was supplemented with linoleate. (2) In confirmation of earlier work the mean percentage of linoleate in the serum lipids of the MS patients was significantly lower (P < 0·01) than in the control subjects in the pre-supplementation period. The mean percentage of oleate showed an increase (P < 0·005) in the patients as compared with the controls while on their normal diets. (3) The period of linoleate feeding produced a considerable rise in the percentage of linoleate together with a fall in the percentage of oleate in both the controls and the MS patients. (4) When large amounts of linoleate, as present in sunflower seed oil, are ingested we have been unable to obtain evidence of a defect in absorption from the intestinal lumen.
（1）在14例多发性硬化症（MS）患者和14名健康受试者中，测量了正常饮食补充亚油酸前后、期间及之后五天血清中亚油酸和油酸的水平。（2）正如早期研究证实的那样，在补充亚油酸前的阶段，MS患者血清脂质中亚油酸的平均百分比显著低于对照组（P < 0·01）。与对照组相比，患者在正常饮食时油酸的平均百分比有所增加（P < 0·005）。（3）补充亚油酸期间，对照组和MS患者血清中亚油酸的百分比均显著上升，油酸的百分比则下降。（4）当摄入大量向日葵籽油中的亚油酸时，我们未能找到肠道腔吸收存在缺陷的证据。
