多发性硬化症中的亚油酸代谢
Linoleate metabolism in multiple sclerosis.
作者信息
Belin J, Pettet N, Smith A D, Thompson R H, Zilkha K J
出版信息
J Neurol Neurosurg Psychiatry. 1971 Feb;34(1):25-9. doi: 10.1136/jnnp.34.1.25.
Abstract
(1) The levels of oleate and linoleate in the serum have been measured in 14 patients with multiple sclerosis (MS) and in 14 healthy subjects before, during and after a five day period when the normal diet was supplemented with linoleate. (2) In confirmation of earlier work the mean percentage of linoleate in the serum lipids of the MS patients was significantly lower (P < 0·01) than in the control subjects in the pre-supplementation period. The mean percentage of oleate showed an increase (P < 0·005) in the patients as compared with the controls while on their normal diets. (3) The period of linoleate feeding produced a considerable rise in the percentage of linoleate together with a fall in the percentage of oleate in both the controls and the MS patients. (4) When large amounts of linoleate, as present in sunflower seed oil, are ingested we have been unable to obtain evidence of a defect in absorption from the intestinal lumen.
摘要
（1）在14例多发性硬化症（MS）患者和14名健康受试者中，测量了正常饮食补充亚油酸前后、期间及之后五天血清中亚油酸和油酸的水平。（2）正如早期研究证实的那样，在补充亚油酸前的阶段，MS患者血清脂质中亚油酸的平均百分比显著低于对照组（P < 0·01）。与对照组相比，患者在正常饮食时油酸的平均百分比有所增加（P < 0·005）。（3）补充亚油酸期间，对照组和MS患者血清中亚油酸的百分比均显著上升，油酸的百分比则下降。（4）当摄入大量向日葵籽油中的亚油酸时，我们未能找到肠道腔吸收存在缺陷的证据。
相似文献
1
Linoleate metabolism in multiple sclerosis.多发性硬化症中的亚油酸代谢
J Neurol Neurosurg Psychiatry. 1971 Feb;34(1):25-9. doi: 10.1136/jnnp.34.1.25.
2
Linoleate and fatty-acid patterns of serum lipids in multiple sclerosis and other diseases.多发性硬化症及其他疾病中血清脂质的亚油酸和脂肪酸模式
Br Med J. 1974 Jul 6;3(5922):18-21. doi: 10.1136/bmj.3.5922.18.
3
Effects of palm-kernel oil and sunflower-seed oil on serum lipids and atherogenesis in alloxan-diabetic rabbits.棕榈仁油和葵花籽油对四氧嘧啶糖尿病兔血脂及动脉粥样硬化形成的影响。
Atherosclerosis. 1975 Nov-Dec;22(3):349-68. doi: 10.1016/0021-9150(75)90016-7.
4
Relationship between plasma and lymphocyte linoleate in multiple sclerosis.多发性硬化症中血浆与淋巴细胞亚油酸酯的关系。
J Neurol Neurosurg Psychiatry. 1976 Aug;39(8):767-71. doi: 10.1136/jnnp.39.8.767.
5
Double-blind trial of linoleate supplementation of the diet in multiple sclerosis.饮食中补充亚油酸对多发性硬化症的双盲试验。
Br Med J. 1973 Mar 31;1(5856):765-8. doi: 10.1136/bmj.1.5856.765.
6
[Effect of short-term administration of sunflower oil on the blood serum level of linoleic and arachidonic acids and lipids in multiple sclerosis].
Neurol Neurochir Pol. 1980 Jan-Feb;14(1):27-37.
7
Linoleate and fatty acid patterns of serum lipids in multiple sclerosis.多发性硬化症患者血清脂质中的亚油酸和脂肪酸模式
Acta Neurol Scand. 1978 Mar;57(3):270-4. doi: 10.1111/j.1600-0404.1978.tb05875.x.
8
Letter: Stability of serum oleate and linoleate levels after oral administration of oleic acid.
Lancet. 1975 Dec 13;2(7946):1216. doi: 10.1016/s0140-6736(75)92714-2.
9
Fatty acid composition of phospholipids from platelets and erythrocytes in multiple sclerosis.多发性硬化症患者血小板和红细胞中磷脂的脂肪酸组成
J Neurol Neurosurg Psychiatry. 1970 Aug;33(4):506-10. doi: 10.1136/jnnp.33.4.506.
10
[A study of lipid metabolism in multiple sclerosis].[多发性硬化症中的脂质代谢研究]
Vopr Med Khim. 1972 Jul-Aug;18(4):376-85.
引用本文的文献
1
Nutritional interventional studies in patients with multiple sclerosis: a scoping review of the current clinical evidence.多发性硬化症患者的营养干预研究：当前临床证据的范围综述。
J Neurol. 2024 Apr;271(4):1536-1570. doi: 10.1007/s00415-023-12140-z. Epub 2024 Jan 4.
2
Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives.膳食补充剂对控制多发性硬化症症状及复发的作用：当前临床证据与未来展望
Medicines (Basel). 2019 Sep 12;6(3):95. doi: 10.3390/medicines6030095.
3
Global untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo β-lactamase, MBLAC1.全球非靶向血清代谢组学分析确定了对孤儿金属β-内酰胺酶MBLAC1表达缺失有反应的代谢途径。
Mol Omics. 2018 Jun 12;14(3):142-155. doi: 10.1039/c7mo00022g.
4
Serial levels of plasma linoleic acid in tetanus.破伤风患者血浆亚油酸的系列水平。
Ir J Med Sci. 1976 Dec;145(1):243. doi: 10.1007/BF02938954.
5
Multiple sclerosis.多发性硬化症
Glob Adv Health Med. 2013 Jan;2(1):50-6. doi: 10.7453/gahmj.2013.2.1.009.
6
Evaluation of the erythrocyte-UFA (E-UFA) mobility test for the diagnosis of multiple sclerosis.红细胞-不饱和脂肪酸（E-UFA）流动性测试用于多发性硬化症诊断的评估。
J Neurol Neurosurg Psychiatry. 1980 Nov;43(11):995-8. doi: 10.1136/jnnp.43.11.995.
7
Levels of linoleate and arachidonate in red blood cells of healthy individuals and patients with multiple sclerosis.健康个体和多发性硬化症患者红细胞中亚油酸和花生四烯酸的水平。
J Neurol Neurosurg Psychiatry. 1980 Feb;43(2):106-10. doi: 10.1136/jnnp.43.2.106.
8
Dietary intake of linoleic acid in multiple sclerosis and other diseases.多发性硬化症及其他疾病中膳食亚油酸的摄入量。
J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):668-73. doi: 10.1136/jnnp.36.4.668.
9
A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis.长链n-3多不饱和脂肪酸治疗多发性硬化症的双盲对照试验。
J Neurol Neurosurg Psychiatry. 1989 Jan;52(1):18-22. doi: 10.1136/jnnp.52.1.18.
10
Supplementation of polyunsaturated fatty acids in multiple sclerosis.
Ital J Neurol Sci. 1992 Jun;13(5):401-7. doi: 10.1007/BF02312146.
本文引用的文献
1
Multiple sclerosis; a correlation of its incidence with dietary fat.多发性硬化症；其发病率与膳食脂肪的相关性。
Am J Med Sci. 1950 Oct;220(4):421-30.
2
ALTERATIONS IN MYELIN FATTY ACIDS AND PLASMALOGENS IN MULTIPLE SCLEROSIS.多发性硬化症中髓鞘脂肪酸和缩醛磷脂的改变
Ann N Y Acad Sci. 1965 Mar 31;122:405-16. doi: 10.1111/j.1749-6632.1965.tb20223.x.
3
Fatty-acid composition of brain lecithins in multiple sclerosis.多发性硬化症中脑卵磷脂的脂肪酸组成
Lancet. 1963 Jan 5;1(7271):26-7. doi: 10.1016/s0140-6736(63)91152-8.
4
Effects of a diet high in polyunsaturated fat on the plasma lipids of normal young females.
J Nutr. 1963 Jan;79(1):85-92. doi: 10.1093/jn/79.1.85.
5
Effects of dietary fats on human erythrocyte fatty acid patterns.膳食脂肪对人体红细胞脂肪酸模式的影响。
J Clin Invest. 1963 May;42(5):675-85. doi: 10.1172/JCI104759.
6
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
7
Deficiency of essential fatty acids and atherosclerosis, etcetera.必需脂肪酸缺乏与动脉粥样硬化等。
Lancet. 1956 Apr 7;270(6919):381-3.
8
Allergic encephalomyelitis induced by brain antigen after deficiency in polyunsaturated fatty acids during myelination. Is multiple sclerosis a nutritive disorder?髓鞘形成过程中多不饱和脂肪酸缺乏后由脑抗原诱导的变应性脑脊髓炎。多发性硬化症是一种营养失调疾病吗？
Acta Neurol Scand. 1967;43(3):375-88. doi: 10.1111/j.1600-0404.1967.tb05740.x.
9
Plasma fatty acids in normolipemic and hyperlipemic subjects during fasting and after linoleate feeding.
Am J Clin Nutr. 1967 Oct;20(10):1057-69. doi: 10.1093/ajcn/20.10.1057.
10
A biochemical approach to the problem of multiple sclerosis.一种针对多发性硬化症问题的生化方法。
Proc R Soc Med. 1966 Mar;59(3):269-76. doi: 10.1177/003591576605900332.
Zotero 插件