Farrell M K, Partin J C, Bove K E
J Pediatr. 1980 Mar;96(3 Pt 2):545-51. doi: 10.1016/s0022-3476(80)80864-x.
A distinctive myopathy was observed in 24 children following influenza B infection. The abrupt onset of severe muscle pain and difficulty in walking began as the respiratory symptoms were waning. The lower extremities, particularly the gastrocnemius and soleus muscles, were involved preferentially. Nasopharyngeal cultures were positive for influenza B Hong Kong in 18 of these patients. Serum creatine phosphokinase levels were significantly elevated (mean 55.2 units) when compared to controls and nine patients with Reye syndrome. The cardiac muscle isoenzyme was detected in the serum of 17 myopathy patients. Serum glutamic oxaloacetic transaminase, but not serum glutamic pyruvic transaminase, was elevated compared to controls (P less than 0.01) but less (P less than 0.001) than the patients with Reye syndrome. Twelve patients underwent muscle biopsy; segmental rhabdomyolysis without inflammation was detected in nine patients. Myopathy is a complication of influenza infection that can be diagnosed by clinical, biochemical, and virologic examination.
在24名感染乙型流感的儿童中观察到一种独特的肌病。严重肌肉疼痛和行走困难突然发作，此时呼吸道症状正在消退。下肢，尤其是腓肠肌和比目鱼肌，优先受累。这些患者中有18例鼻咽培养物乙型流感香港株呈阳性。与对照组和9例瑞氏综合征患者相比，血清肌酸磷酸激酶水平显著升高（平均55.2单位）。在17例肌病患者的血清中检测到心肌同工酶。与对照组相比，血清谷草转氨酶升高，但谷丙转氨酶未升高（P<0.01），但低于瑞氏综合征患者（P<0.001）。12例患者接受了肌肉活检；9例患者检测到无炎症的节段性横纹肌溶解。肌病是流感感染的一种并发症，可通过临床、生化和病毒学检查进行诊断。
