药物制剂中洗必泰的快速比色分析

Rapid colorimetric analysis of chlorhexidine in pharmaceutical preparations.

作者信息

Andermann G, Buhler M O, Erhart M

出版信息

J Pharm Sci. 1980 Feb;69(2):215-7. doi: 10.1002/jps.2600690229.

Abstract

A colorimetric determination of chlorhexidine is described. The method is based on the formation of a yellow complex between the drug and bromcresol green. The absorption peak of this complex, extracted by chloroform, is at 410 nm, and linear response is obtained from 2.5 to 30 micrograms of chlorhexidine/ml. The accuracy and reproducibility of this rapid method make it useful for chlorhexidine determination in the manufacturing control of pharmaceutical mixtures.

摘要

本文描述了一种比色法测定洗必泰。该方法基于药物与溴甲酚绿之间形成黄色络合物。用氯仿萃取该络合物的吸收峰在410nm处，在2.5至30微克洗必泰/毫升范围内获得线性响应。这种快速方法的准确性和可重复性使其可用于药物混合物生产控制中的洗必泰测定。