Ambrose S S, Parrott T S, Woodard J R, Campbell W G
J Urol. 1980 Mar;123(3):349-51. doi: 10.1016/s0022-5347(17)55929-7.
Of 63 patients with reflux and renal atrophy renal dysplasia was found in 9.5 per cent. Pyelonephritis was apparent in 81 per cent of the atrophic lesions. Urinary obstruction or ectasia was apparent in each case with dysplasia and only 2 were associated with histologic evidence of pyelonephritis. Pyelonephritis appears to be a major causal factor in atrophy occurring in renal units with reflux. Early urinary tract obstruction or distension may predispose to renal dysplasia.
在63例有反流和肾萎缩的患者中，发现9.5%有肾发育异常。81%的萎缩性病变有肾盂肾炎。在每例发育异常的病例中均可见尿路梗阻或扩张，仅有2例伴有肾盂肾炎的组织学证据。肾盂肾炎似乎是反流性肾单位萎缩的主要致病因素。早期尿路梗阻或扩张可能易导致肾发育异常。
