Fukuda S, Kopple J D
Nephron. 1980;25(3):139-43. doi: 10.1159/000181770.
11 adult female dogs were given periodic intravenous injections of uranyl nitrate [UO2(NO3)2 . 6H2O] to create a syndrome of chronic uremia. Initially, dogs usually received 2.0 mg/kg of uranyl nitrate; subsequent doses were generally less. After the initial injection, there was an abrupt fall in creatinine clearance and rise in plasma urea nitrogen. Low and relatively constant creatinine clearances (10.2 +/- SD 2.7 ml/min) were easily maintained with further injections. Dogs developed proteinuria, aminoaciduria, weight loss, and plasma amino acid levels similar to those of chronically uremic humans and rats. With creatinine clearances of 4 ml/min or less, dogs became listless and lethargic, and daily activity and food intake decreased. Repeated injections of uranyl nitrate appear to be an easy and reliable method for creating a model of chronic uremia in dogs.
给11只成年雌性犬定期静脉注射硝酸铀酰[UO₂(NO₃)₂·6H₂O]以制造慢性尿毒症综合征。最初，犬通常接受2.0mg/kg硝酸铀酰；随后的剂量一般较少。首次注射后，肌酐清除率急剧下降，血浆尿素氮升高。通过进一步注射很容易维持较低且相对恒定的肌酐清除率（10.2±标准差2.7ml/分钟）。犬出现蛋白尿、氨基酸尿、体重减轻，且血浆氨基酸水平与慢性尿毒症患者和大鼠相似。当肌酐清除率降至4ml/分钟或更低时，犬变得无精打采、嗜睡，日常活动和食物摄入量减少。重复注射硝酸铀酰似乎是在犬中制造慢性尿毒症模型的一种简单可靠的方法。
