叶酸对红细胞酸性磷酸酶（ACP）抑制作用中的表型依赖性。
Phenotype dependence in the inhibition of red cell acid phosphatase (ACP) by folates.
作者信息
Sensabaugh G F, Golden V L
出版信息
Am J Hum Genet. 1978 Sep;30(5):553-60.
Abstract
Red cell acid phosphatase (ACP) is shown to be inhibited by folic acid and various folates. The degree of inhibition is phenotype dependent with a pattern of variation differing from that of the well recognized variation in red cell activity levels. The pattern of variation is ordered ACP1B less than ACP1A less than ACP1C in terms of the relative allelic contributions to the observed inhibition. This pattern correlates with previously observed patterns of risk for two hemolytic disorders and may thus provide a key to their understanding.
摘要
红细胞酸性磷酸酶（ACP）被证明会受到叶酸和各种叶酸盐的抑制。抑制程度取决于表型，其变化模式与红细胞活性水平中广为人知的变化模式不同。就对观察到的抑制的相对等位基因贡献而言，变化模式为ACP1B小于ACP1A小于ACP1C。这种模式与先前观察到的两种溶血性疾病的风险模式相关，因此可能为理解它们提供关键线索。
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