Prasad N, Prasad R, Thornby J, Harrell J E, Hudgins P T
Oncology. 1980;37(2):107-10. doi: 10.1159/000225415.
In vivo and in vitro survival and response of lymphocytes were studied in 12 lung cancer patients before, during and following radiotherapy, and comparisons were made to data from 20 healthy control subjects. Lymphocyte counts of lung cancer patients prior to radiotherapy did not differ significantly from those of control subjects. Following radiotherapy, lymphocyte counts were significantly reduced. The in vitro survival of lymphocytes from lung cancer patients prior to radiotherapy was lower than that of normal controls. Radiation treatment had no effect on lymphocyte survival in vitro. PHA-stimulated lymphoblast formation in lung cancer patients prior to radiotherapy did not differ from that of normal controls, but decreased significantly during radiotherapy.
对12例肺癌患者放疗前、放疗期间及放疗后的淋巴细胞进行了体内和体外存活及反应研究，并与20名健康对照者的数据进行了比较。肺癌患者放疗前的淋巴细胞计数与对照者无显著差异。放疗后，淋巴细胞计数显著降低。肺癌患者放疗前淋巴细胞的体外存活率低于正常对照。放射治疗对淋巴细胞的体外存活无影响。肺癌患者放疗前PHA刺激的淋巴母细胞形成与正常对照无差异，但在放疗期间显著减少。
