Wallace R B, Sherman B M, Bean J A
Oncology. 1980;37(2):111-3. doi: 10.1159/000225416.
A history of prior total bilateral oophorectomy and exogenous estrogen use was elicited from 45 women with breast surgery for cancer, 19 of whose neoplasms were estrogen receptor (ER) positive and 26 ER negative. In the ER-positive group there was a history of oophorectomy in 0/19 and estrogen use in 3/19. In the ER-negative group, corresponding values were 8/26 and 12/26 (p less than 0.05). Manipulation of the female hormonal milieu during or prior to the menopause may be related to the subsequent ER status of incident breast cancers.
对45例行乳腺癌手术的女性进行了既往双侧卵巢全切术及外源性雌激素使用情况的调查，其中19例肿瘤为雌激素受体（ER）阳性，26例ER阴性。在ER阳性组中，19例中有0例有卵巢切除术史，3例有雌激素使用史。在ER阴性组中，相应数值分别为26例中的8例和12例（p<0.05）。绝经期间或绝经前对女性激素环境的干预可能与后续发生的乳腺癌的ER状态有关。
