Gapinski P V, Donegan W L
Surgery. 1980 Sep;88(3):386-93.
From a review of clinical material, relationships were investigated between tumor estrogen receptors (ER) in breast cancers and (1) response of metastases to chemotherapy or endocrine therapy in 54 patients and (2) prognosis after mastectomy in 274 patients. Considering more than 300 femtomoles of ER per gram of tissue ER "rich" for premenopausal women and more than 700 ER rich for postmenopausal women, 14 of 20 patients (70%) with ER-rich tumors responded to endocrine therapy, whereas only one of 21 (4.8%) with ER-poor tumors responded. The probability of response appeared to increase with the concentration of ER. No correlation could be found between ER status and responsiveness to chemotherapy. Compared with patients with primary tumors poor in ER, those with ER-rich tumors had less recurrence after mastectomy, a longer free interval, and a more favorable disease-free survival, The 8S and 4S fractions of ER had similar relationships to tumor response and prognosis.
通过对临床资料的回顾，研究了乳腺癌肿瘤雌激素受体（ER）与以下两方面的关系：（1）54例患者转移灶对化疗或内分泌治疗的反应；（2）274例患者乳房切除术后的预后。对于绝经前女性，每克组织中ER超过300飞摩尔为ER“丰富”，绝经后女性超过700为ER丰富，20例ER丰富肿瘤患者中有14例（70%）对内分泌治疗有反应，而21例ER缺乏肿瘤患者中只有1例（4.8%）有反应。反应的可能性似乎随ER浓度增加。未发现ER状态与化疗反应性之间存在相关性。与ER缺乏的原发肿瘤患者相比，ER丰富的肿瘤患者乳房切除术后复发较少，无瘤间期较长，无病生存期更有利。ER的8S和4S组分与肿瘤反应和预后有相似的关系。
