Melman A, Henry D P, Felten D L, O'Connor B
South Med J. 1980 Mar;73(3):307-9, 317. doi: 10.1097/00007611-198003000-00010.
Samples of erectile tissue taken from the corpora cavernosa of 16 male diabetic patients suffering from impotence were studied. The content of norepinephrine, which reflects sympathetic nerve activity of that tissue, was significantly lower in insulin-dependent patients 104.2 +/- 24.8 (SE) pg/mg wet weight (P less than .001) and diet-controlled patients 483.7 +/- 103.7 (P less than .01) than the normal men (881.7 +/- 62.0). Myelinated and unmyelinated nerve fibers were observed intact and unaltered in each group of patients. The results indicated that normally a dense adrenergic innervation of human erectile tissue is present, but that a reduction occurs in norepinephrine content in diabetic patients with impotence. It appears, however, that the anatomic integrity of the sympathetic nerves is intact. The presence of intact nerve fibers along with a diminished content of neurotransmitter suggests the possibility of pharmacologic treatment of impotence.
对16名患有阳痿的男性糖尿病患者阴茎海绵体的勃起组织样本进行了研究。反映该组织交感神经活动的去甲肾上腺素含量，在胰岛素依赖型患者中显著降低，为104.2±24.8（标准误）皮克/毫克湿重（P＜0.001），在饮食控制的患者中为483.7±103.7（P＜0.01），均低于正常男性（881.7±62.0）。在每组患者中均观察到有髓和无髓神经纤维完整无损。结果表明，正常情况下人类勃起组织存在密集的肾上腺素能神经支配，但患有阳痿的糖尿病患者去甲肾上腺素含量会降低。然而，交感神经的解剖完整性似乎是完好的。完整神经纤维的存在以及神经递质含量的减少提示了阳痿药物治疗的可能性。
