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糖尿病阴茎中血管活性肠肽样免疫反应性神经。链脲佐菌素处理大鼠与人的比较。

Vasoactive intestinal polypeptide-like immunoreactive nerves in diabetic penis. A comparison between streptozotocin-treated rats and man.

作者信息

Crowe R, Lincoln J, Blacklay P F, Pryor J P, Lumley J S, Burnstock G

出版信息

Diabetes. 1983 Nov;32(11):1075-7. doi: 10.2337/diab.32.11.1075.

DOI:10.2337/diab.32.11.1075
PMID:6357906
Abstract

Vasoactive intestinal polypeptide (VIP) has been demonstrated by immunofluorescence histochemistry in nerves in human and rat penile tissue. A reduction in VIP-like immunoreactivity in nerves was revealed in tissue from streptozotocin-diabetic rats and a human diabetic with impotence. These results suggest that an impairment in the VIP-ergic innervation in penile tissue may be an important factor in the development of impotence in diabetes. They also support the view that the streptozotocin-treated rat is a useful experimental model for diabetic autonomic neuropathy.

摘要

通过免疫荧光组织化学已证实在人和大鼠阴茎组织的神经中存在血管活性肠肽（VIP）。在链脲佐菌素诱导的糖尿病大鼠和一名患有阳痿的糖尿病患者的组织中，发现神经中VIP样免疫反应性降低。这些结果表明，阴茎组织中VIP能神经支配受损可能是糖尿病性阳痿发生的一个重要因素。它们还支持这样一种观点，即链脲佐菌素处理的大鼠是糖尿病自主神经病变的有用实验模型。

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引用本文的文献

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Regulation of tone in penile cavernous smooth muscle. Established concepts and new findings.阴茎海绵体平滑肌张力的调节。既定概念与新发现。
World J Urol. 1994;12(5):249-61. doi: 10.1007/BF00191204.
2
Elevated levels of vasoactive intestinal peptide in the eye and urinary bladder of diabetic and prediabetic Chinese hamsters.糖尿病和糖尿病前期中国仓鼠的眼睛和膀胱中血管活性肠肽水平升高。
Diabetologia. 1985 May;28(5):302-7. doi: 10.1007/BF00271690.
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Experimental diabetes mellitus inhibits prostacyclin synthesis by the rat penis: pathological implications.
实验性糖尿病抑制大鼠阴茎前列环素的合成：病理学意义。
Diabetologia. 1985 Jun;28(6):365-8. doi: 10.1007/BF00283145.
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Autonomic neuromuscular junctions: current developments and future directions.自主神经肌肉接头：当前进展与未来方向。
J Anat. 1986 Jun;146:1-30.
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Vasoactive intestinal polypeptide levels and distribution in the penis of old rats.
J Neural Transm. 1987;70(1-2):137-43. doi: 10.1007/BF01252515.
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Depletion of cutaneous nerves and neuropeptides in diabetes mellitus: an immunocytochemical study.糖尿病患者皮肤神经和神经肽的耗竭：一项免疫细胞化学研究。
Diabetologia. 1989 Jul;32(7):427-33. doi: 10.1007/BF00271262.
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Changes in the somatostatin, substance P and vasoactive intestinal polypeptide content of the gastrointestinal tract following streptozotocin-induced diabetes in the rat.链脲佐菌素诱导大鼠糖尿病后胃肠道中生长抑素、P物质和血管活性肠肽含量的变化
Diabetologia. 1985 Jun;28(6):355-8. doi: 10.1007/BF00283143.
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