Galton V A
Am J Physiol. 1978 Dec;235(6):E628-33. doi: 10.1152/ajpendo.1978.235.6.E628.
The effects of hyperoxia at ambient pressure on thyroid function and thyroid hormone metabolism have been assessed. Thyroidal activity was depressed in mice and rats by exposure to hyperoxia, due at least in part to a decrease in the rate of secretion of pituitary thyrotropin. The effects of hyperoxia on the peripheral deiodination of thyroxine (T4) were dependent on the concentration of oxygen employed and/or the duration of exposure; exposure to 40--80% oxygen for 96 h resulted in decreases in the rate of deiodination and in the deiodinative clearance of [125I]T4. Hyperoxia also resulted in a marked fall in the serum concentration of endogenous T4 and a decrease in T4-binding activity in serum. Many of these effects of hyperoxia were prevented by the concomitanat administration of large amounts of vitamin E (alpha-tocopherol acetate). These decreases in thyroid function and T4 metabolism were associated with a decrease in the rate of whole body oxygen consumption. Thus, the deleterious effects of oxygen in the rat were not due, even in part, to an oxygen-induced hyperthyroid state in the peripheral tissues.
已评估常压下高氧对甲状腺功能和甲状腺激素代谢的影响。暴露于高氧环境中，小鼠和大鼠的甲状腺活性受到抑制，这至少部分归因于垂体促甲状腺激素分泌速率的降低。高氧对甲状腺素（T4）外周脱碘的影响取决于所用氧气浓度和/或暴露持续时间；暴露于40%-80%氧气中96小时会导致脱碘速率以及[125I]T4的脱碘清除率降低。高氧还导致内源性T4血清浓度显著下降以及血清中T4结合活性降低。同时给予大量维生素E（α-生育酚醋酸酯）可预防高氧的许多这些影响。甲状腺功能和T4代谢的这些降低与全身耗氧率降低有关。因此，大鼠中氧气的有害作用即使部分也并非由于外周组织中氧气诱导的甲状腺功能亢进状态。
