Olesen O V, Thomsen K
Acta Pharmacol Toxicol (Copenh). 1980 Mar;46(3):185-90. doi: 10.1111/j.1600-0773.1980.tb02441.x.
The effects of infusion of potassium chloride was studied in Wistar rats given lithium by the food for more than 3 weeks. The animals were anaesthetized with amytal and three clearance periods were run. During periods 1 and 3 0.15 M NcCl was infused at a rate of 0.02 ml/min. for 60 min. and in period 2 0.5 M KCl was infused at the same rate for 90 min. Potassium infusion led to an increase of potassium excretion. Sodium excretion and urine flow were positive linear correlated to the potassium excretion but in rats given lithium the effect of potassium on sodium excretion was about eight times higher and the effect on urine flow about thirteen times higher than the effects on control rats not given lithium. The concentration of Na and K in the urine of the lithium-treated group were within a narrow range and almost unaffected by potassium infusion. Lithium clearance and the fractional excretion of lithium rose significantly during potassium infusion. Inulin clearance was almost unaffected by the potassium infusion. The results indicate that potassium infusion in rats given lithium for prolonged time leads to an increase of renal sodium, water and lithium excretion.
在通过食物给予锂超过3周的Wistar大鼠中研究了氯化钾输注的效果。动物用戊巴比妥麻醉，并进行了三个清除期。在第1期和第3期，以0.02 ml/min的速率输注0.15 M氯化钠60分钟，在第2期，以相同速率输注0.5 M氯化钾90分钟。钾输注导致钾排泄增加。钠排泄和尿流与钾排泄呈正线性相关，但在给予锂的大鼠中，钾对钠排泄的影响比未给予锂的对照大鼠高约8倍，对尿流的影响高约13倍。锂治疗组尿液中钠和钾的浓度在狭窄范围内，几乎不受钾输注的影响。在钾输注期间，锂清除率和锂的分数排泄显著升高。菊粉清除率几乎不受钾输注的影响。结果表明，长时间给予锂的大鼠输注钾会导致肾钠、水和锂排泄增加。
