Lönnerdal B, Forsum E, Hambraeus L
Am J Clin Nutr. 1980 Apr;33(4):816-24. doi: 10.1093/ajcn/33.4.816.
Nitrogen and protein composition was determined in milk from women using oral contraceptives during lactation. Total nitrogen and nonprotein nitrogen as well as lactose and the individual milk proteins lactoferrin, alpha-lactalbumin, and serum albumin were analyzed before introduction of oral contraceptives and thereafter throughout the lactation period. Twenty-four hour milk volumes were registered by weighing the infant before and after each feeding. The four oral contraceptives used consisted of different combinations of d-norgestrel, megestrolacetate, and ethinylestradiol. Significant changes were observed between groups and controls for all parameters studied. However, the changes observed were generally within the physiological variation of normal breast milk. It is suggested that the use of oral contraceptives during lactation should be limited.
对哺乳期使用口服避孕药的女性所产乳汁中的氮和蛋白质成分进行了测定。在引入口服避孕药之前以及此后整个哺乳期，分析了总氮、非蛋白氮以及乳糖和乳汁中的个别蛋白质，即乳铁蛋白、α-乳白蛋白和血清白蛋白。通过在每次喂奶前后称量婴儿体重来记录24小时的乳汁量。所使用的四种口服避孕药由炔诺孕酮、甲地孕酮和炔雌醇的不同组合构成。在所有研究参数方面，观察组和对照组之间均观察到了显著变化。然而，所观察到的变化总体上处于正常母乳的生理变化范围内。建议哺乳期口服避孕药的使用应受到限制。
