Judd H L, Davidson B J, Frumar A M, Shamonki I M, Lagasse L D, Ballon S C
Am J Obstet Gynecol. 1980 Apr 1;136(7):859-71. doi: 10.1016/0002-9378(80)91043-1.
Thirty-five consecutive patients with adenocarcinoma of the endometrium and an equal number of control subjects matched to the cancer patients for age and percentage of ideal weight were studied prospectively. In the cancer patients, the mean +/- SE serum androstenedione, testosterone, estrone (E1) and estradiol (E2) levels were 503 +/- 34 pg/ml, 224 +/- 22 pg/ml, 38.7 +/- 3.6 pg/ml, and 14.5 +/- 0.9 pg/ml, respectively. Similar concentrations were found in the control subjects. Body weight and percentage of ideal weight showed highly significant correlations (P less than 0.001) with E1 and E2 but not with the androgen concentrations in either group. The heavier patients had higher E1 and E2 levels. Age and years since menopause did not correlate with any of the hormonal levels. The cancer patients with overt diabetes tended to be more obese and have higher estrogen levels than did the nondiabetic subjects. Those with a history of prior estrogen usage were more slender and had lower endogenous estrogens than the nonusers. Twenty-three of the cancer patients (66%) had a presumed risk factor(s) for the development of this tumor, that is, excess body weight, high endogenous estrogen levels, or a history of prior estrogen usage. These data support the concept that conditions which lead to continued, unopposed estrogen stimulation may be associated with malignant transformation of the endometrium.
对35例连续的子宫内膜腺癌患者以及与癌症患者年龄和理想体重百分比相匹配的同等数量的对照受试者进行了前瞻性研究。癌症患者中，血清雄烯二酮、睾酮、雌酮（E1）和雌二醇（E2）水平的均值±标准误分别为503±34 pg/ml、224±22 pg/ml、38.7±3.6 pg/ml和14.5±0.9 pg/ml。在对照受试者中发现了类似的浓度。体重和理想体重百分比与E1和E2呈高度显著相关性（P＜0.001），但与两组中的雄激素浓度均无相关性。体重较重的患者E1和E2水平较高。年龄和绝经后的年限与任何激素水平均无相关性。患有明显糖尿病的癌症患者往往比非糖尿病患者更肥胖且雌激素水平更高。有过雌激素使用史的患者比未使用者更苗条且内源性雌激素水平更低。23例癌症患者（66%）具有该肿瘤发生的推测危险因素，即体重超标、内源性雌激素水平高或有过雌激素使用史。这些数据支持这样一种概念，即导致持续、无对抗性雌激素刺激的情况可能与子宫内膜的恶性转化有关。
