Hayashi T T, MacFarlane K
Am J Obstet Gynecol. 1980 Apr 1;136(7):897-903. doi: 10.1016/0002-9378(80)91048-0.
The incorporation a of 3H-leucine was studied in male rats and female rats 14 and 19 days pregnant that were either fed or starved for 48 hours. 3H-leucine incorporation into the liver was similar among all the fed animals. There was a 40% to 50% increase in the 3H-leucine incorporation of the placenta and fetus per milligram of ribonucleic acid from the fourteenth to the nineteenth day of pregnancy. With starvation there was a significant increase in 3H-leucine incorporation in both the fetus and the placenta of the 19-day-pregnant animal associated with a significant decrease in liver incorporation. Yolk sac placenta demonstrated a greater increase than the allantoic placenta. Both the male and 14-day-pregnant animals had minimal changes with starvation. The problems inherent in studying protein synthesis, especially during pregnancy, are presented.
研究了3H-亮氨酸在雄性大鼠以及怀孕14天和19天的雌性大鼠中的掺入情况，这些大鼠要么喂食要么饥饿48小时。在所有喂食的动物中，3H-亮氨酸掺入肝脏的情况相似。从怀孕第14天到第19天，每毫克核糖核酸中胎盘和胎儿的3H-亮氨酸掺入量增加了40%至50%。饥饿时，怀孕19天动物的胎儿和胎盘的3H-亮氨酸掺入量显著增加，同时肝脏掺入量显著减少。卵黄囊胎盘的增加幅度大于尿囊胎盘。雄性和怀孕14天的动物在饥饿时变化最小。文中还介绍了研究蛋白质合成，尤其是在怀孕期间研究蛋白质合成所固有的问题。
