Genta R M, Ward P A
Am J Pathol. 1980 Apr;99(1):207-20.
An investigation of the pathologic events occurring during experimental Strongyloides ratti infection in rats was done. The chronologic sequence of the cellular responses to the infecting larvae as they migrated through the skin and lungs was determined. Larvae penetrate the skin very quickly, eliciting considerable mast cell degranulation within the first few minutes, a modest neutrophil response within the first few hours, and an occasional mononuclear response within the first 2 days. The larval passage in the lungs appears to cause little damage except for microhemorrhages and an occasional microabscess. In the intestine S ratti adult worms lie in the cryptae without penetrating mucosa, and except for an increase in the number of mast cells at the time of expulsion (Days 20--25), there is no detectable cellular response. Differences from the human disease are discussed.
对大鼠实验性感染鼠类圆线虫期间发生的病理事件进行了研究。确定了机体对感染性幼虫在穿过皮肤和肺部时细胞反应的时间顺序。幼虫很快穿透皮肤，在最初几分钟内引起大量肥大细胞脱颗粒，在最初几小时内引起适度的中性粒细胞反应，在最初2天内偶尔出现单核细胞反应。幼虫在肺部移行似乎除了引起微出血和偶尔的微脓肿外，几乎不造成损害。在肠道中，鼠类圆线虫成虫位于隐窝内，不穿透黏膜，除了在排出成虫时（第20 - 25天）肥大细胞数量增加外，未检测到细胞反应。文中讨论了与人类疾病的差异。
