Moqbel R, Denham D A
Parasitology. 1978 Jun;76(3):289-98. doi: 10.1017/s0031182000048162.
Rats were treated with betamethasone at different stages of infection with Strongyloides ratti. Treatment caused a diminution in the number of adult worms recovered but this residual population was not expelled as were worms from untreated rats. If treatment was started after expulsion had already begun adult worm numbers increased--suggesting that autoinfection occurred. Treatment throughout a primary infection prevented the development of an immune response which expelled, or killed, a challenge infection. Treatment, just before and just after challenge, prevented the expulsion of the challenge infection. Worm expulsion up to day 35 was prevented by treating rats with betamethasone 4, 6, 8 and 10 days after infection.
用倍他米松对感染鼠类圆线虫不同阶段的大鼠进行治疗。治疗导致回收的成虫数量减少，但与未治疗大鼠的蠕虫不同，这一残留群体并未被排出。如果在排出已经开始后开始治疗，成虫数量会增加——这表明发生了自身感染。在初次感染期间进行全程治疗可阻止免疫反应的发展，而这种免疫反应会排出或杀死激发感染。在激发感染之前和之后立即进行治疗可阻止激发感染的排出。在感染后4、6、8和10天用倍他米松治疗大鼠可阻止直至第35天的蠕虫排出。
