Rosen P P, Cantrell B, Mullen D L, DePalo A
Am J Surg Pathol. 1980 Feb;4(1):3-12.
Thirty-seven cases of juvenile papillomatosis of the breast were reviewed. The average age was 19 years (range 10-44 years). On examination the patients usually had a localized, multinodular mass that was interpreted as a fibroadenoma. Microscopically, typical lesions featured papillomatosis, sometimes with severe atypia, cysts with or without apocrine metaplasia, duct stasis, and sclerosing adenosis. In one case the breast with papillomatosis adenosis. In one case the breast with papillomatosis has remained free of carcinoma, but at the time of biopsy the patient had secretory carcinoma of the other breast. Papillomatous changes were not observed in the breast with carcinoma. Another woman had lobular carcinoma in situ coexisting with juvenile papillomatosis. After an average follow-up of 8 years, no subsequent carcinoma has been found. Thus, there appears to be little risk for early onset of carcinoma, but without additional follow-up the long-term assessment of this disorder remains uncertain. We recommend that a patient with juvenile papillomatosis have a thorough clinical examination of the breasts at least once a year.
回顾了37例乳腺青少年乳头状瘤病。平均年龄为19岁（范围10 - 44岁）。检查时，患者通常有一个局限性、多结节性肿块，被诊断为纤维腺瘤。显微镜下，典型病变特征为乳头状瘤病，有时伴有重度异型性、有或无大汗腺化生的囊肿、导管淤滞和硬化性腺病。1例患者乳腺有乳头状瘤性腺病。1例患乳头状瘤病的乳腺未发生癌变，但活检时患者另一侧乳腺有分泌性癌。癌变的乳腺中未观察到乳头状改变。另一名女性小叶原位癌与青少年乳头状瘤病共存。平均随访8年后，未发现后续癌变。因此，似乎早期发生癌变的风险很小，但未经额外随访，对该疾病的长期评估仍不确定。我们建议患有青少年乳头状瘤病的患者每年至少进行一次全面的乳腺临床检查。
