Kataev S V, Brodinova N S, Moroz A F
Antibiotiki. 1980 Mar;25(3):188-93.
Activity of 10 antibiotics, 6 surface active substances, 1 antioxidant and boric acid against P. aeruginosa, E. coli, Pr. vulgaris and Staph. aureus most frequently vegetating in burn wounds was studied. It was found that gentamicin had the highest antibacterial effect on the above organisms. Polymyxin M had a pronounced antimicrobial action on P. aeruginosa and E. coli. A significant antibacterial effect with respect to Staph. aureus, E. coli and Pr. vulgaris was observed with the use of the drugs of the nitrofuran line, i.e. salaful, furagin and furacillin. These drugs were not active against P. aeruginosa. A high antimicrobial effect with respect to all of the test-microbed used was recorded with methacyl, a surface active substance. To show the synergistic effect on the microbes most frequently vegetating in burn wounds, the antibacterial action of the drug combinations was studied. The synergistic effect (16 to 100 times) was observed with the use of polymyxin M combination with mafenide, carbenicillin with gentamicin, methacide with fenozan. The microorganisms tested were resistant to boric acid. On the basis of the study the most effective drugs and their combinations were chosen for their addition to the algipores (polymer coatings) used in treatment of burns infected with the above microbes.
研究了10种抗生素、6种表面活性物质、1种抗氧化剂和硼酸对烧伤创面最常见的铜绿假单胞菌、大肠杆菌、普通变形杆菌和金黄色葡萄球菌的活性。发现庆大霉素对上述微生物的抗菌效果最高。多粘菌素M对铜绿假单胞菌和大肠杆菌有显著的抗菌作用。使用硝基呋喃类药物，即沙罗夫、呋喃西林和呋苄西林，对金黄色葡萄球菌、大肠杆菌和普通变形杆菌观察到显著的抗菌效果。这些药物对铜绿假单胞菌无活性。表面活性物质甲酰对所有测试微生物均有很高的抗菌效果。为了显示对烧伤创面最常见微生物的协同作用，研究了药物组合的抗菌作用。使用多粘菌素M与磺胺米隆、羧苄西林与庆大霉素、甲酰与非诺赞的组合观察到协同作用（16至100倍）。测试的微生物对硼酸耐药。基于该研究，选择了最有效的药物及其组合添加到用于治疗上述微生物感染烧伤的藻酸盐（聚合物涂层）中。
