Li A K, Ehrlich H P, Trelstad R L, Koroly M J, Schattenkerk M E, Malt R A
Ann Surg. 1980 Feb;191(2):244-8. doi: 10.1097/00000658-198002000-00019.
Circular, full-thickness dermal burn- and freeze-produced wounds were produced in rats to compare the difference in healing between the two types of thermal injuries. Contraction did not occur in wounds (n = 30) caused by freezing, while burn wounds (n = 30) contracted to less than one-third of original size by 21 days after injury. If the centers of the freeze-produced wounds (n = 12) were excised, contraction would then occur and proceed at the same rate as an open wound. Histologically, the degree of initial tissue destruction by the two types of injuries was similar. The burn wound contained only half the amount of collagen found in the freeze-produced wound. There was a greater and more rapid replacement of collagen in the burn wounds. With both injuries, the highest concentration of collagen was found on the fifteenth day and returned to normal by the twenty-eighth day. The burn wound contained three times the amount of collagen in normal skin, while the freeze-produced wound contained only 1 3/4 times the amount in normal skin. Contraction does not seem to occur in the healing of the freeze-injured skin because the slow removal and replacement of the residual matrix prevents contraction.
在大鼠身上制造圆形全层皮肤烧伤和冻伤伤口，以比较这两种热损伤类型在愈合方面的差异。冻伤造成的伤口（n = 30）未出现收缩，而烧伤伤口（n = 30）在受伤后21天收缩至原始大小的三分之一以下。如果切除冻伤伤口（n = 12）的中心部位，伤口就会开始收缩，且收缩速度与开放性伤口相同。从组织学角度来看，两种损伤造成的初始组织破坏程度相似。烧伤伤口中的胶原蛋白含量仅为冻伤伤口的一半。烧伤伤口中胶原蛋白的替代过程更迅速且量更多。两种损伤情况下，胶原蛋白浓度在第15天达到最高，到第28天恢复正常。烧伤伤口中的胶原蛋白含量是正常皮肤的三倍，而冻伤伤口中的胶原蛋白含量仅为正常皮肤的1又3/4倍。冻伤皮肤愈合过程中似乎不会发生收缩，因为残余基质的缓慢清除和替代阻碍了收缩。
