Ondreyco S M, Lewis H D, Hartman C R
Arch Intern Med. 1980 Apr;140(4):547-9.
Although valvular lesions are rare in acromegaly, two patients with click-murmur syndrome and one patient with aortic insufficiency secondary to myxomatous degeneration and cystic medial necrosis of the aorta have been reported. Growth hormone excess has been postulated to potentiate these connective tissue defects. Excess mucopolysaccharide deposition is stimulated by growth hormone and is characteristic of both cystic medial necrosis and myxomatous degeneration. Both lesions are found in experimental lathyrism, which is potentiated by growth hormone. We observed a patient with mitral insufficiency, acromegaly documented by growth hormone levels, myxomatous degeneration of all four cardiac valves, and cystic medial necrosis of the aorta and pulmonary artery. This case presents further evidence that excess growth hormone may potentiate the connective tissue cardiovascular lesions in acromegaly.
虽然瓣膜病变在肢端肥大症中很少见，但已有报道称有两名患有喀喇音-杂音综合征的患者以及一名继发于主动脉黏液瘤样变性和囊性中层坏死的主动脉瓣关闭不全患者。有人推测生长激素过多会加剧这些结缔组织缺陷。生长激素会刺激黏多糖过度沉积，这是囊性中层坏死和黏液瘤样变性的特征。这两种病变都见于实验性山黧豆中毒，且生长激素会加剧这种情况。我们观察到一名二尖瓣关闭不全患者，其生长激素水平证实患有肢端肥大症，所有四个心脏瓣膜均有黏液瘤样变性，主动脉和肺动脉有囊性中层坏死。该病例进一步证明，生长激素过多可能会加剧肢端肥大症患者的结缔组织心血管病变。
