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脑脊液中的多巴胺β-羟化酶。与人格测量的关系。

Dopamine beta-hydroxylase in CSF. Relationship to personality measures.

作者信息

Major L F, Lerner P, Goodwin F K, Ballenger J C, Brown G L, Lovenberg W

出版信息

Arch Gen Psychiatry. 1980 Mar;37(3):308-10. doi: 10.1001/archpsyc.1980.01780160078009.

DOI:10.1001/archpsyc.1980.01780160078009
PMID:7362418
Abstract

Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, was measured in the CSF of 32 subjects. Those individuals with a low level of DBH in the CSF had significantly elevated profiles on the Minnesota Multiphasic Personality Inventory, suggesting a relationship between the central noradrenergic system and some aspects of personality in man.

摘要

多巴胺β-羟化酶(DBH)是一种将多巴胺转化为去甲肾上腺素的酶,在32名受试者的脑脊液中进行了测量。脑脊液中DBH水平较低的个体在明尼苏达多相人格问卷上的得分显著升高,这表明中枢去甲肾上腺素能系统与人类人格的某些方面之间存在关联。

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引用本文的文献

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A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders.功能性多巴胺-β-羟化酶基因启动子多态性与冲动型人格类型相关,但与情感障碍无关。
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2
Biodevelopmental aspects of conduct disorder in boys.男孩品行障碍的生物发育方面
Child Psychiatry Hum Dev. 1993 Winter;24(2):125-41. doi: 10.1007/BF02367265.
3
Psychological effects of dopamine beta-hydroxylase inhibition: a failure to replicate.
多巴胺β-羟化酶抑制的心理效应:一项未能重复的研究。
Psychopharmacology (Berl). 1983;79(4):352-6. doi: 10.1007/BF00433417.