Hartmann E, Oldfield M, Adelman S, Edelberg R
Psychopharmacology (Berl). 1983;79(4):352-6. doi: 10.1007/BF00433417.
In a previous investigation of whether reduced dopamine-beta-hydroxylase (DBH) might play a role in schizophrenia, we studied the effects of DBH inhibition for a few hours in normal subjects. This initial study showed positive effects, i.e., unusual subjective psychological reports confirmed by psychiatric rating scales, in subjects given the DBH inhibitor fusaric acid. The present study attempted to replicate these findings using a more detailed battery of tests and an additional control situation. Each subject underwent the following four treatment conditions at 1-week intervals: fusaric acid plus L-dopa; L-dopa alone; d-amphetamine; placebo. The present results did not confirm those of the first study. A few interesting results were found that were chiefly attributable to amphetamine effects. No effect could be definitely attributed to fusaric acid.
在先前一项关于多巴胺-β-羟化酶（DBH）降低是否可能在精神分裂症中起作用的调查中，我们研究了在正常受试者中抑制DBH数小时的效果。这项初步研究显示了积极效果，即在给予DBH抑制剂丁烯酸的受试者中，不寻常的主观心理报告经精神病学评定量表证实。本研究试图通过使用更详细的一系列测试和额外的对照情况来重复这些发现。每个受试者每隔1周接受以下四种治疗条件：丁烯酸加左旋多巴；单独使用左旋多巴；右旋苯丙胺；安慰剂。目前的结果并未证实第一项研究的结果。发现了一些有趣的结果，这些结果主要归因于苯丙胺的作用。没有效果可以明确归因于丁烯酸。
