[慢性肝病时小肠黏膜上皮细胞的超微结构变化]

[Ultrastructural changes in the epithelial cells of the small intestine mucosa in chronic liver diseases].

作者信息

Gerlovin E Sh, Reĭskanen A V, Iakhontova O I

出版信息

Arkh Patol. 1980;42(2):27-31.

Abstract

Electron microscopy of epithelial cells of the mucous membrane of the duodenum and jejunum was performed in 20 patients with chronic hepatitis and liver cirrhosis to reveal changes in the structure of intracellular formations of epithelial cells of the cryptae and villi, of goblet and enterochromaffin cells. The most essential differences were found in mitochondria, granular cytoplasmic network, ribosomes, microvilli and glycocalix. There were no differences in the pattern of cellular changes in chronic hepatitis and liver cirrhosis. However, the degree of lesions increased in patients with liver cirrhosis. Morphologic changes seen in the mucous membrane of the small intestine (duodenitis and jejunitis) in chronic liver diseases present the morphologic substrate of digestion impaired by these diseases.

摘要

对20例慢性肝炎和肝硬化患者的十二指肠和空肠黏膜上皮细胞进行了电子显微镜检查，以揭示隐窝和绒毛的上皮细胞、杯状细胞和肠嗜铬细胞的细胞内结构变化。在线粒体、颗粒状细胞质网络、核糖体、微绒毛和糖萼中发现了最本质的差异。慢性肝炎和肝硬化患者的细胞变化模式没有差异。然而，肝硬化患者的病变程度有所增加。慢性肝病时小肠黏膜（十二指肠炎和空肠炎）出现的形态学变化是这些疾病导致消化功能受损的形态学基础。