[Adenovirus antigens in the cells of affected skin and immunohistochemical shifts in psoriasis].

Immunohistochemical analysis of skin biopsies of 35 psoriatic patients is performed. Adenovirus antigens in the cells of perivascular infiltrates of the syncitial and papillary layers of the antigens were not detected in epitheliocytes and this allows considering the epidermal lesions and epidermal proliferation as caused by connective tissue alteration with subsequent loss of regulation control by basal cells. These processes are followed by immune disorders and inflammatory reaction as local manifestation of general disease. Deposits of immune complexes (C3-component, IgG, viral antigen), fibrin, albumin, C-reactive protein, destruction of cell and fibrillar connective tissue components followed by the inflammatory response result in the alteration of cell interaction in the connective tissue and dermo-epidermal interrelations and this is a basic mechanism of the damage to epidermis and its proliferation.