Sanders R R, Lee W H, Koh L, Brennecke A, Jones W R
Br J Obstet Gynaecol. 1980 Feb;87(2):139-41. doi: 10.1111/j.1471-0528.1980.tb04507.x.
Plasma prostaglandin F (PGF) was measured by a radioimmunoassay method in 24 subjects with tumours of the female genital tract. Levels in the tumour group ranged from 25 pg/ml to 134 pg/ml and were almost all greater than the values observed in a control group of 41 healthy women who had a mean (+/-SD) level of 21 (+/-3.4)pg/ml. There was a relationship between plasma PGF levels and the stage of the disease. Patients with resectable tumours showed a fall in PGF levels postoperatively and those with disseminated malignancy demonstrated increasing levels as the disease progressed. Plasma PGF may provide a clinical prognostic marker in the management of patients with malignant tumours.
采用放射免疫分析法对24例女性生殖道肿瘤患者的血浆前列腺素F（PGF）进行了测定。肿瘤组的PGF水平在25 pg/ml至134 pg/ml之间，几乎均高于41名健康女性组成的对照组，该对照组的平均（±标准差）水平为21（±3.4）pg/ml。血浆PGF水平与疾病分期之间存在关联。可切除肿瘤患者术后PGF水平下降，而播散性恶性肿瘤患者随着疾病进展PGF水平升高。血浆PGF可能为恶性肿瘤患者的管理提供一种临床预后标志物。
