大鼠早产。II. 低温的影响。

Prematurity in the rat. II. Effect of hypothermia.

作者信息

Cuezva J M, Benito M, Moreno F J, Medina J M

出版信息

Biol Neonate. 1980;37(3-4):218-23. doi: 10.1159/000241277.

Abstract

The time-courses of liver glycogen, plasma glucose, lactate, alanine and glycerol concentrations in term and preterm rats undergoing hypothermia (30 degrees C) during the first 2 h after delivery have been studied. Hypothermia prevented liver glycogenolysis and the neonatal decrease of plasma glucose concentration in term and preterm rats during the first 2 h after delivery. Hypothermia decreased plasma glucose, lactate and alanine utilization but increased plasma glycerol concentration. These results suggest that hypothermia blunts the utilization of the main metabolic substrates but increases brown adipose tissue lipolysis for thermogenesis.

摘要

研究了足月和早产大鼠在出生后最初2小时内进行低温（30摄氏度）处理时，肝脏糖原、血浆葡萄糖、乳酸、丙氨酸和甘油浓度的时间进程。低温可防止足月和早产大鼠在出生后最初2小时内出现肝脏糖原分解及新生儿血浆葡萄糖浓度下降。低温降低了血浆葡萄糖、乳酸和丙氨酸的利用，但增加了血浆甘油浓度。这些结果表明，低温减弱了主要代谢底物的利用，但增加了棕色脂肪组织的脂肪分解以产生热量。