Sandhu R S, Conover R E
Clin Biochem. 1980 Feb;13(1):30-3. doi: 10.1016/s0009-9120(80)90502-0.
We report a case of metastatic adenocarcinoma of the prostate with widespread bony and hepatic involvement having extremely high BB isoenzyme of creatine kinase in serum (2405 U/liter). The serum LD5/LD1 ratio is greater than one, with total LD activity more than twenty-five fold the normal value. The homogenate of prostate gland of the patient shows an extra band with electrophoretic mobility between MM and MB isoenzymes of creatine kinase and highly elevated LD5 fraction compared to LD1 (33% vs. 9%), a remarkable LD isoenzyme pattern of malignant prostate tissue.
我们报告一例前列腺转移性腺癌，伴有广泛的骨和肝转移，血清肌酸激酶BB同工酶极高（2405 U/升）。血清LD5/LD1比值大于1，总LD活性超过正常值的25倍。患者前列腺匀浆在肌酸激酶MM和MB同工酶之间显示出一条电泳迁移率异常的条带，且LD5组分相对于LD1显著升高（33%对9%），这是恶性前列腺组织显著的LD同工酶模式。
