Prenna M, Ripa S
Chemotherapy. 1980;26(2):98-102. doi: 10.1159/000237889.
Single doses of 250 and 500 mg of BL-S 578 (cefadroxil), a new semisynthetic cephalosporin, were orally administered to 13 normal, healthy volunteers and serum levels determined at timed intervals for 7 h. Peak concentration was obtained at 1 1/2 h after administration of 250 mg (8.981 micrograms/ml) or 500 mg (17.861 micrograms/ml). Urniary excretion levels within 24 h after ingestion of single doses of 250 and 500 mg of cefadroxil were 89.92 and 86.34%, respectively.
对13名正常健康志愿者口服单剂量250毫克和500毫克的新型半合成头孢菌素BL-S 578（头孢羟氨苄），并在7小时内定时测定血清水平。服用250毫克（8.981微克/毫升）或500毫克（17.861微克/毫升）后1.5小时达到峰值浓度。单次服用250毫克和500毫克头孢羟氨苄后24小时内的尿排泄水平分别为89.92%和86.34%。
