Mariño E L, Dominguez-Gil A
Eur J Clin Pharmacol. 1980 Nov;18(6):505-9. doi: 10.1007/BF00874664.
The pharmacokinetics of Cefadroxil have been studied in a crossover study involving 20 experiments in four healthy volunteers (19--24 years), after oral administration of five individual doses of 250, 500, 750, 1000 and 1500 mg of the antibiotic in capsules to each person. Plasma and urine concentrations of the antibiotic were determined microbiologically by a plate diffusion method. The antibiotic followed an open, single-compartment kinetic model. The plasma half-life was not significantly influenced by dose; the average was 1.438 +/- 0.220 h. The percentage of the antibiotic excreted in urine, too, was not significantly affected by the dose, being close to 80% of the quantity originally administered within 24 h. The values of Cmax and (AUC) increased linearly with the administered dose.
在一项交叉研究中，对4名健康志愿者（19 - 24岁）口服5种单剂量（分别为250、500、750、1000和1500毫克）胶囊装头孢羟氨苄后的药代动力学进行了研究，每人每次服用一种剂量，共进行20次实验。采用平板扩散法通过微生物学方法测定血浆和尿液中抗生素的浓度。该抗生素遵循开放的单室动力学模型。血浆半衰期不受剂量的显著影响；平均值为1.438±0.220小时。尿液中排泄的抗生素百分比也不受剂量的显著影响，在24小时内接近最初给药量的80%。Cmax和（AUC）值随给药剂量呈线性增加。
