Grande P, Naestoft J, Christiansen C
Eur J Cardiol. 1980 Jan;11(1):71-7.
The purpose of this study was to determine a simple and reliable procedure of estimating acute myocardial infarct (AMI) size by measuring serum creatine kinase MB (CK-MB) in few daily blood samples. In 13 patients with AMI blood samples were drawn every second hour for 60 h for determination of serum CK-MB activity. Infarct size was calculated using the CK-MB values of all samples and compared to the size calculated according to various models based on enzyme levels in few samples. Two models, using 3 daily samples, showed very high correlations and satisfactory standard errors of estimate when compared to the infarct size calculated from all samples. One of the 2 models was based on a computerized log-normal curve fit programme and one on accumulation of serum activities of CK-MB. The coefficient of variation of infarct size estimated from thrice-daily sampling was 7.4 and 9.4 for the 2 models. Considering the twenty-fold variation in infarct size a satisfactory quantitation is achieved from 3 daily samples.
本研究的目的是通过在每日少量血样中测量血清肌酸激酶同工酶（CK-MB）来确定一种简单可靠的估计急性心肌梗死（AMI）面积的方法。13例AMI患者每两小时采集一次血样，共采集60小时，用于测定血清CK-MB活性。使用所有样本的CK-MB值计算梗死面积，并与根据少数样本中酶水平的各种模型计算的面积进行比较。两个模型，使用3个每日样本，与根据所有样本计算的梗死面积相比，显示出非常高的相关性和令人满意的估计标准误差。这两个模型中的一个基于计算机化的对数正态曲线拟合程序，另一个基于CK-MB血清活性的累积。两个模型从每日三次采样估计的梗死面积变异系数分别为7.4和9.4。考虑到梗死面积有20倍的变化，从3个每日样本中可实现令人满意的定量。
