• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Systemic activity of orally administered L-dopa in the elderly Parkinson patient.

作者信息

Evans M A, Triggs E J, Broe G A, Saines N

出版信息

Eur J Clin Pharmacol. 1980;17(3):215-21. doi: 10.1007/BF00561903.

DOI:10.1007/BF00561903
PMID:7363934
Abstract
摘要

相似文献

1
Systemic activity of orally administered L-dopa in the elderly Parkinson patient.老年帕金森病患者口服左旋多巴的全身活性
Eur J Clin Pharmacol. 1980;17(3):215-21. doi: 10.1007/BF00561903.
2
Gastric emptying rate and the systemic availability of levodopa in the elderly parkinsonian patient.
Neurology. 1981 Oct;31(10):1288-94. doi: 10.1212/wnl.31.10.1288.
3
Intestinal decarboxylation of orally administered L-dopa. Influence of pharmacological preparations, dose magnitude, dose sequence and food intake.口服左旋多巴的肠道脱羧作用。药理制剂、剂量大小、给药顺序和食物摄入的影响。
Acta Med Scand. 1975 Nov;198(5):415-20.
4
Variations in L-dopa absorption. Report of a parkinsonian patient with high plasma dopa concentration after therapeutical L-dopa dose.左旋多巴吸收的变化。一例帕金森病患者在接受治疗剂量左旋多巴后血浆多巴浓度升高的报告。
Acta Med Scand. 1974 Dec;196(6):459-63.
5
Dosage form design for improvement of bioavailability of levodopa II: bioavailability of marketed levodopa preparations in dogs and parkinsonian patients.提高左旋多巴生物利用度的剂型设计II：市售左旋多巴制剂在犬类和帕金森病患者中的生物利用度
J Pharm Sci. 1980 May;69(3):261-5. doi: 10.1002/jps.2600690304.
6
Senile Parkinsonism and dopa pharmacokinetics.
Clin Exp Neurol. 1981;18:174-9.
7
Effect of anticholinergic drugs on gastro-intestinal absorption of L-dopa in rats and in man.抗胆碱能药物对大鼠和人体中左旋多巴胃肠道吸收的影响。
Eur J Pharmacol. 1976 Feb;35(2):293-9. doi: 10.1016/0014-2999(76)90231-4.
8
Peripheral pharmacokinetics of levodopa in untreated, stable, and fluctuating parkinsonian patients.
Neurology. 1987 Jun;37(6):940-4. doi: 10.1212/wnl.37.6.940.
9
Conjugation of L-DOPA and its metabolites after oral and intravenous administration to Parkinsonian patients.左旋多巴及其代谢产物在帕金森病患者口服和静脉给药后的结合情况。
Biochem Pharmacol. 1975 Jul 15;24(13-14):1317-20. doi: 10.1016/0006-2952(75)90345-7.
10
The effect of carbidopa on the pharmacokinetics of intravenously administered levodopa: the mechanism of action in the treatment of parkinsonism.卡比多巴对静脉注射左旋多巴药代动力学的影响：治疗帕金森病的作用机制。
Ann Neurol. 1985 Nov;18(5):537-43. doi: 10.1002/ana.410180505.

引用本文的文献

1
Little Change in Functional Brain Networks Following Acute Levodopa in Drug-Naïve Parkinson's Disease.急性左旋多巴治疗对初发帕金森病患者的功能性脑网络影响较小。
Mov Disord. 2020 Mar;35(3):499-503. doi: 10.1002/mds.27942. Epub 2019 Dec 19.
2
A randomised clinical trial to evaluate the effects of Plantago ovata husk in Parkinson patients: changes in levodopa pharmacokinetics and biochemical parameters.一项评估车前子壳对帕金森病患者影响的随机临床试验：左旋多巴药代动力学和生化参数的变化。
BMC Complement Altern Med. 2014 Aug 12;14:296. doi: 10.1186/1472-6882-14-296.
3
Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease.

本文引用的文献

1
The metabolism of L-3-O-methyldopa, a precursor of dopa in man.
Clin Pharmacol Ther. 1971 Jul-Aug;12(4):678-82. doi: 10.1002/cpt1971124678.
2
Plasma DOPA response to levodopa administration in man: effects of a peripheral decarboxylase inhibitor.
Clin Pharmacol Ther. 1971 Mar-Apr;12(2):212-7. doi: 10.1002/cpt1971122part1212.
3
L-dopa treatment failure: explanation and correction.左旋多巴治疗失败：解释与纠正。
Br Med J. 1970 Oct 10;4(5727):93-4. doi: 10.1136/bmj.4.5727.93.
4
用于治疗帕金森病的药物的临床药代动力学和药效学特性。
Clin Pharmacokinet. 2002;41(4):261-309. doi: 10.2165/00003088-200241040-00003.
4
Drug dosage in the elderly. Is it rational?老年人的药物剂量。合理吗？
Drugs Aging. 1998 Nov;13(5):357-79. doi: 10.2165/00002512-199813050-00003.
5
Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical implications.老年人的药代动力学和药效学变化。临床意义。
Clin Pharmacokinet. 1998 Jul;35(1):49-64. doi: 10.2165/00003088-199835010-00004.
6
Drug-induced orthostatic hypotension in the elderly: avoiding its onset.老年人药物性体位性低血压：避免其发生。
Drug Saf. 1997 Aug;17(2):105-18. doi: 10.2165/00002018-199717020-00003.
7
Sustained-release of levodopa: single dose study of a new formulation.左旋多巴缓释剂：一种新剂型的单剂量研究
J Neural Transm (Vienna). 1996;103(6):717-27. doi: 10.1007/BF01271231.
8
Individual variation in first-pass metabolism.首过代谢的个体差异。
Clin Pharmacokinet. 1993 Oct;25(4):300-28. doi: 10.2165/00003088-199325040-00005.
9
Drug-induced orthostatic hypotension in older patients.老年患者药物性体位性低血压
Drugs Aging. 1995 Mar;6(3):219-28. doi: 10.2165/00002512-199506030-00005.
10
Intestinal absorption of levodopa in man.左旋多巴在人体肠道的吸收情况。
Eur J Clin Pharmacol. 1983;25(1):69-72. doi: 10.1007/BF00544017.
Dihydroxyphenylalanine (DOPA) in plasma during dopa treatment of patients with Parkinson's disease.帕金森病患者接受多巴治疗期间血浆中的二羟基苯丙氨酸（DOPA）
Mayo Clin Proc. 1970 Jun;45(6):438-43.
5
Metabolism and absorption of L-3,4 dihydroxyphenylalanine in patients with Parkinson's disease.帕金森病患者中L-3,4-二羟基苯丙氨酸的代谢与吸收
Ann N Y Acad Sci. 1971 Jul 6;179:126-40. doi: 10.1111/j.1749-6632.1971.tb46895.x.
6
Absorption and metabolism of levodopa.
JAMA. 1971 Dec 27;218(13):1912-4.
7
A method for the determination of dopa and 3-O-methyldopa in the plasma of Parkinsonian patients.
Clin Chim Acta. 1972 Mar;37:335-41. doi: 10.1016/0009-8981(72)90453-6.
8
Studies on the metabolism of D- and L-isomers of 3,4-dihydroxyphenylalanine (DOPA). V. Mechanism of intestinal absorption of D- and L-DOPA-14C in rats.3,4-二羟基苯丙氨酸（多巴）的D-和L-异构体代谢研究。V. 大鼠体内D-和L-多巴-14C的肠道吸收机制。
Chem Pharm Bull (Tokyo). 1973 Sep;21(9):2031-8. doi: 10.1248/cpb.21.2031.
9
[L-dopa in 122 cases of Parkinson's disease in patients over 70 years old. Comparative study with a group of Parkinsonian patients who are 41 to 69 years old].[左旋多巴用于122例70岁以上帕金森病患者。与一组41至69岁帕金森病患者的对照研究]
Gerontol Clin (Basel). 1973;15(1):50-64. doi: 10.1159/000245433.
10
[Fluroimetric determination of sub-micromolar amounts of DOPA in plasma].[血浆中亚微摩尔量多巴的荧光测定]
Clin Chim Acta. 1973 May 30;45(4):423-7. doi: 10.1016/0009-8981(73)90044-2.