急性左旋多巴治疗对初发帕金森病患者的功能性脑网络影响较小。
Little Change in Functional Brain Networks Following Acute Levodopa in Drug-Naïve Parkinson's Disease.
机构信息
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
John Cochrane VA Medical Center, Neurology Section, St. Louis, Missouri, USA.
出版信息
Mov Disord. 2020 Mar;35(3):499-503. doi: 10.1002/mds.27942. Epub 2019 Dec 19.
Abstract
OBJECTIVE
The objective of this study was to investigate the effects of levodopa on functional brain networks in Parkinson's disease.
METHODS
We acquired resting state functional magnetic resonance imaging in 30 drug-naïve participants with Parkinson's disease and 20 age-matched healthy controls. Each participant was studied following administration of a single oral dose of either levodopa or placebo in a randomized, double-blind, crossover design.
RESULTS
The greatest observed differences in functional connectivity were between Parkinson's disease versus control participants, independent of pharmacologic intervention. By contrast, the effects of levodopa were much smaller and detectable only in the Parkinson's disease group. Moreover, although levodopa administration in the Parkinson's disease group measurably improved motor performance, it did not increase the similarity of functional connectivity in Parkinson's disease to the control group.
CONCLUSIONS
We found that a single, small dose of levodopa did not normalize functional connectivity in drug-naïve Parkinson's disease. © 2019 International Parkinson and Movement Disorder Society.
摘要
目的
本研究旨在探讨左旋多巴对帕金森病患者大脑功能网络的影响。
方法
我们招募了 30 名未经药物治疗的帕金森病患者和 20 名年龄匹配的健康对照者进行静息态功能磁共振成像研究。每位参与者均采用随机、双盲、交叉设计，在接受单剂量左旋多巴或安慰剂治疗后进行研究。
结果
与药物干预无关，观察到的功能连接差异最大的是帕金森病患者与对照组之间的差异。相比之下，左旋多巴的作用要小得多，只能在帕金森病组中检测到。此外，尽管帕金森病组中左旋多巴的给药可显著改善运动表现，但并未增加帕金森病组与对照组功能连接的相似性。
结论
我们发现，单次小剂量左旋多巴并不能使未经药物治疗的帕金森病患者的功能连接正常化。© 2019 国际帕金森病和运动障碍学会。
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