Horn F, Gebhart W, Luger T
Ann Dermatol Venereol. 1978 Jun-Jul;105(6-7):581-5.
In this report, we wish to demonstrate histological and ultrastructural characteristics of transient acantholytic dermatosis, first described in 1970 by Grover. Papules on the upper part of the body and on the arms and thighs are noted in our two patients. They are small in size (2-4 mm) and encircled by an erythematous border; pruritus and vesicles with serous content are often present. The vesicles are follicular and tend to group. Biological and immunological studies are normal. Histological examination shows acantholysis and intraepidermal vesicles above which is hyperkeratosis with parakeratosis. In the dermis, inflammatory infiltrates are noted. Ultrastructural study reveals rarefaction of desmosomes and widening of intercellular spaces. Fragments of tonofibrils are also noted. Karyolysis is sometimes present. The dermis contains A. Civatte's bodies. It is likely that this recently identified disease is less unfrequent than it appears to be.
在本报告中，我们希望展示1970年由格罗弗首次描述的暂时性棘层松解性皮病的组织学和超微结构特征。我们的两名患者身上出现了位于身体上部、手臂和大腿上的丘疹。它们体积较小（2 - 4毫米），周围有红色边缘；常伴有瘙痒和含浆液的水疱。水疱为毛囊性且倾向于成群分布。生物学和免疫学研究结果正常。组织学检查显示棘层松解和表皮内水疱，水疱上方为角化过度伴角化不全。在真皮层可见炎症浸润。超微结构研究显示桥粒稀疏、细胞间隙增宽。还可见张力原纤维片段。有时存在核溶解现象。真皮层含有西瓦特小体。这种最近才被确认的疾病可能并不像看起来那么罕见。
