溶原性对肺炎链球菌转化的抑制作用。
Inhibition of transformation in Streptococcus pneumoniae by lysogeny.
作者信息
Moynet D J, Tiraby G J
出版信息
J Bacteriol. 1980 Mar;141(3):1298-304. doi: 10.1128/jb.141.3.1298-1304.1980.
Abstract
Streptococcus pneumoniae R6X was lysogenized with bacteriophage 304 isolated after mitomycin induction of an ungrouped alpha-hemolytic streptococcus. Lysogenized pneumococci lost their capacity to undergo genetic transformation: transformability was restored after cells were spontaneously cured of their prophage. Both lysogens and nonlysogens produced activator substance (competence factor), and both bound deoxyribonucleic acid in a deoxyribonuclease-resistant form. However, nonlysogens retained deoxyribonucleic acid after washing, whereas lysogens did not. The latter did not liberate phage nor (unlike nonlysogens) degrade transforming deoxyribonucleic acid and contained normal levels of endonuclease.
摘要
肺炎链球菌R6X用从经丝裂霉素诱导的未分组α-溶血链球菌中分离出的噬菌体304进行溶源化处理。溶源化的肺炎球菌失去了进行遗传转化的能力：当细胞自发去除原噬菌体后，转化能力得以恢复。溶源菌和非溶源菌都产生激活物质（感受态因子），并且二者都以抗脱氧核糖核酸酶的形式结合脱氧核糖核酸。然而，非溶源菌在洗涤后保留了脱氧核糖核酸，而溶源菌则没有。后者既不释放噬菌体，也不像非溶源菌那样降解转化性脱氧核糖核酸，并且含有正常水平的内切核酸酶。
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