Hadler N M
J Biol Chem. 1980 Apr 25;255(8):3532-5.
The diffusion coefficients for glucose and sucrose within matrices of hyaluronic acid are contrasted with coefficients determined in matrices of agarose. Diffusivity is similar in 0.5 and 1% matrices of both polysaccharide polymers dissolved in saline (0.9% NaCl solution) buffered at pH 7.4 with 0.01 M sodium phosphate. In a 2.5% matrix of hyaluronate, but not agarose, glucose diffusivity is enhanced 3-fold, whereas simultaneously determined sucrose diffusivity remains unchanged from that in the 1% matrix. The 1% hyaluronate matrix will enhance glucose diffusivity if an inorganic cationic serum constituent(s) with a molecular weight of less than 500 is incorporated into the solvent. This enhanced diffusivity is inversely dependent on glucose concentration and on the degree of polymerization of the hyaluronate in the matrix. The presence of an appropriately constituted matrix of hyaluronic acid endows the resultant fluid with several properties generally ascribed to membranes: permselectivity (even glucose and sucrose behave differently), saturability, and the potential to enhance translational movement of selected solutes such as glucose.
将透明质酸基质中葡萄糖和蔗糖的扩散系数与琼脂糖基质中测定的系数进行对比。在溶解于pH值为7.4、用0.01M磷酸钠缓冲的生理盐水（0.9%NaCl溶液）中的两种多糖聚合物的0.5%和1%基质中，扩散率相似。在2.5%的透明质酸盐基质中而非琼脂糖基质中，葡萄糖扩散率提高了3倍，而同时测定的蔗糖扩散率与1%基质中的相比保持不变。如果将分子量小于500的无机阳离子血清成分掺入溶剂中，1%的透明质酸盐基质会提高葡萄糖扩散率。这种增强的扩散率与葡萄糖浓度以及基质中透明质酸的聚合度呈反比。适当构成的透明质酸基质的存在赋予所得流体一些通常归因于膜的特性：渗透选择性（甚至葡萄糖和蔗糖的行为也不同）、饱和性以及增强所选溶质（如葡萄糖）平移运动的潜力。
