Hadler N M, Dourmashkin R R, Nermut M V, Williams L D
Proc Natl Acad Sci U S A. 1982 Jan;79(2):307-9. doi: 10.1073/pnas.79.2.307.
Freeze-etch replicas of a hylauronic acid matrix were visualized by electron microscopy. In water a coarse branching fibrillar network of hyaluronic acid aggregates was seen. The high solvent permeability of this matrix suggests that the spaces observed are relatively devoid of unaggregated polymer. Addition of calcium disordered the matrix, resulting in a more dispersed felt of polymer.
通过电子显微镜观察了透明质酸基质的冷冻蚀刻复制品。在水中，可以看到由透明质酸聚集体构成的粗大分支纤维状网络。该基质的高溶剂渗透性表明观察到的空间相对缺乏未聚集的聚合物。添加钙会扰乱基质，导致聚合物形成更分散的毡状物。
