Gelberman R H, Amiel D, Rudolph R M, Vance R M
J Bone Joint Surg Am. 1980 Apr;62(3):425-32.
Fascial specimens were obtained from twenty-four patients treated operatively for Dupuytren's contracture. The nodules and cords were examined by electron microscopic and biochemical techniques. The clinical course and response to operative treatment were then correlated with the tissue findings. Electron microscopic analysis revealed myofibroblasts in the nodules of seven of twenty-four patients. Fibroblasts containing prominent microtubules were found in ten patients. The fascia contained type-III collagen, increased amounts of collagen per unit of dry weight, and an increase in reducible cross-links of collagen. While the nodules were noted to contain a greater increase in reducible cross-links than the cords, there was little variation in the biochemical findings from patient to patient. Clinical recurrence was not related to the age of the patient at onset, duration, or severity of disease. Recurrence was related to the electron microscopic findings of myofibroblasts in the nodules and fibroblasts containing prominent microtubules in the fascia of these patients.
从24例接受手术治疗的杜普伊特伦挛缩症患者身上获取筋膜样本。通过电子显微镜和生化技术对结节和条索进行检查。然后将临床病程和手术治疗反应与组织学发现进行关联分析。电子显微镜分析显示，24例患者中有7例的结节中存在肌成纤维细胞。10例患者的成纤维细胞含有突出的微管。筋膜含有III型胶原蛋白，每单位干重的胶原蛋白含量增加，且胶原蛋白的可还原交联增加。虽然结节中的可还原交联增加幅度大于条索，但患者之间的生化结果差异不大。临床复发与患者发病年龄、病程或疾病严重程度无关。复发与这些患者结节中的肌成纤维细胞以及筋膜中含有突出微管的成纤维细胞的电子显微镜检查结果有关。
