Nemetschek T, Meinel A, Nematschek-Gansler H, Reill P, Riedl H
Virchows Arch A Pathol Anat Histol. 1976 Nov 22;372(1):57-74. doi: 10.1007/BF00429717.
Regarding experimental data on the multi-factorial reduction of the thermostability of collagen, the following sequence of the mechanism of Dupuytren's contracture is discussed: 1. Hereditary or acquired weakness of fibres of the palmar fascia 2. Further disturbance of the physical property of collagen by the cumulative effects of mechanical, i.e. traumatic, influence. 3. By this means an induced stepwise shrinkage of released fascial fibres in body temperature. 4. Stabilisation of the shortening (contracture) by development of collagen. This hypothesis is supported by histological, polarizing-microscopic, electron-microscopic and chemical results.
关于胶原蛋白热稳定性多因素降低的实验数据，探讨了掌腱膜挛缩症的如下发病机制顺序：1. 掌腱膜纤维的遗传性或后天性薄弱。2. 机械性（即创伤性）影响的累积效应进一步扰乱胶原蛋白的物理性质。3. 由此导致在体温下释放的筋膜纤维逐步收缩。4. 胶原蛋白形成使缩短（挛缩）得以稳定。这一假说得到了组织学、偏振显微镜、电子显微镜及化学研究结果的支持。
