米安色林的药代动力学。
The pharmacokinetics of mianserin.
作者信息
Shami M, Elliott H L, Kelman A W, Whiting B
出版信息
Br J Clin Pharmacol. 1983;15 Suppl 2(Suppl 2):313S-322S. doi: 10.1111/j.1365-2125.1983.tb05880.x.
Abstract
1 The pharmacokinetics of mianserin hydrochloride have been determined in eight normal healthy volunteers, mean age 27, and 14 elderly patients, mean age 76. 2 Mianserin was administered to volunteers by intravenous infusion (0.011 mg/kg/min for 15 min) and, on another occasion, by mouth, in a single dose of 30 mg. Elderly patients received a single oral dose of 40-60 mg. 3 The terminal elimination half-life was significantly prolonged in the elderly. In young subjects it was 9.6 +/- 1.9 (s.d.) h. In the elderly it was 27 +/- 13.1 (s.d.) h. 4 Apparent oral clearance was significantly reduced in the elderly. In young subjects it was 87.1 +/- 32 (s.d.) h. In the elderly, it was 38.1 +/- 14.8 (s.d.) h. 5 These kinetic differences may have an important bearing on the sedative effects of mianserin.
摘要
- 已在8名平均年龄27岁的正常健康志愿者和14名平均年龄76岁的老年患者中测定了盐酸米安色林的药代动力学。2. 志愿者通过静脉输注（0.011毫克/千克/分钟，持续15分钟）给药米安色林，另一次则口服单剂量30毫克。老年患者接受单剂量40 - 60毫克的口服给药。3. 老年患者的终末消除半衰期显著延长。在年轻受试者中为9.6±1.9（标准差）小时。在老年患者中为27±13.1（标准差）小时。4. 老年患者的表观口服清除率显著降低。在年轻受试者中为87.1±32（标准差）小时。在老年患者中为38.1±14.8（标准差）小时。5. 这些动力学差异可能对米安色林的镇静作用有重要影响。
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本文引用的文献
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