Melamed E, Mildworf B, Sharav T, Belenky L, Wertman E
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
Ann Neurol. 1987 Aug;22(2):275-8. doi: 10.1002/ana.410220215.
Regional cerebral blood flow was measured in 14 patients with Down's syndrome, in 46 patients with Alzheimer's disease and senile dementia of the Alzheimer type, and in 114 age-matched controls, using the xenon 133 inhalation technique. Cerebral blood flow was reduced in 13 of 14 Down's patients by a mean of 16.8 +/- 2.5% from expected age-matched normal values. Degrees of regional cerebral blood flow reduction did not differ among the frontal, temporal, parietal, and occipital regions in both cerebral hemispheres. The regional cerebral blood flow decreases were similar in magnitude and pattern to those in Alzheimer patients. These findings constitute an additional similarity between the two disorders.
采用氙133吸入技术，对14例唐氏综合征患者、46例阿尔茨海默病及阿尔茨海默型老年痴呆患者，以及114例年龄匹配的对照者进行了局部脑血流量测定。14例唐氏患者中有13例脑血流量较预期年龄匹配的正常数值平均降低了16.8±2.5%。大脑两半球的额叶、颞叶、顶叶和枕叶区域的局部脑血流量减少程度无差异。局部脑血流量减少的幅度和模式与阿尔茨海默病患者相似。这些发现构成了这两种疾病之间的又一相似之处。
