Vargar V, Pedreira J D, Esteban R, Ruíz J, Hernández J M, Guardia J, Bacardi R
Med Clin (Barc). 1980 Mar 25;74(6):214-6.
In the present work radioimmunoassay technique detecting antibodies have been used to diagnose viral hepatitis type A. Twenty-nine patients with sporadic acute hepatitis were studied. All of the cases were negative to surface antigen of viral hepatitis type B. Blood samples were obtained at the onset of clinical picture and on subsequent weeks. Antibody levels (anti-hepatitis virus A) showed a significant increase between the second and the sixth week in 21 cases (72.4 percent). An increased antibody titer in a single determination, however, is not sufficient for the diagnosis of hepatitis virus A, since antibodies against such virus are present in a large percentage of the normal population. At least two augmented titers in consecutive samples are necessary to diagnose viral hepatitis type A.
在本研究中，采用放射免疫测定技术检测抗体来诊断甲型病毒性肝炎。对29例散发性急性肝炎患者进行了研究。所有病例的乙型肝炎表面抗原均为阴性。在临床表现出现时及随后几周采集血样。抗体水平（抗甲型肝炎病毒）在21例患者（72.4%）中于第二周和第六周之间显著升高。然而，单次测定中抗体滴度升高不足以诊断甲型肝炎病毒，因为正常人群中很大比例的人都存在针对该病毒的抗体。诊断甲型病毒性肝炎需要连续样本中至少有两次升高的滴度。
